Betting nugget: The Bills have covered four straight games as the favorite. See Week 2 rankings. The Broncos' rushers fared a bit better against the Titans, averaging 4.1 yards per carry, but they enter Sunday's matchup with a question about Phillip Lindsay's availability. -- Jamison Hensley, Bold prediction: Mahomes will complete six throws of at least 20 yards. -- David Newton, Any Day Can Be Draft DayWith our live draft lobby, you can be drafting a team in minutes. Cimini's pick: Patriots 22, Jets 17 How well Darnold handles duress will be key for Carolina keeping pace. Power shift in NFC North? But in its past 20 games as a road favorite, San Francisco is 13-7 ATS. SF-NYJ | MIN-IND | DET-GB PickCenter | ESPN Chalk Cimini's pick: Patriots 22, Jets 17 Read more. The Bucs also will be without starting cornerback Sean Murphy-Bunting. -- Adam Teicher. The Jaguars are making Henry their top priority -- they might get hurt by the pass game, but they're not going to let Henry beat them again. Those plays are always there for him against a Ravens team that blitzes a lot but leaves itself vulnerable to big throws. Betting nugget: The Lions have covered in six straight games against the Packers. FPI prediction: KC, 55.7% (by an average of 2.1 points), Matchup must-reads: A promise to his father: Why Orlando Brown left the Ravens for the Chiefs Ravens promote veteran RB Freeman to active roster Chiefs, Mahomes know it can't be just Hill and Kelce Jackson says he's not dwelling on past losses as Ravens prepare to face Mahomes, Chiefs, Monday, 8:15 p.m. 4:25 p.m. -- Jeff Legwold. Watson led the NFL with two such games in 2018, led again in 2019 with three such games and was one of two quarterbacks (Josh Allen) to accomplish the feat in Week 1 this season. Betting nugget: Chicago is 1-6 ATS in its past seven games as a favorite. -- Lindsey Thiry. But he has been around league average each of the past two seasons, so it's reasonable to expect him to bounce back. Everything you need to know for the NFL's post-Thanksgiving Week 12 games, including bold predictions, key stats, fantasy advice and score picks. Stat to know: Jacksonville, dating back to last season, is on the verge of losing 17 straight games, which would be tied for the fourth-longest losing streak since the merger in 1970. FPI prediction: GB, 67.4% (by an average of 6.5 points), Matchup must-reads: Don't call it a blueprint (yet), but Saints showed how to give Rodgers fits Goff earns admirers in comeback attempt vs. 49ers Lions CB Okudah out for year with ruptured Achilles, Guide to every Week 2 NFL game: Picks, matchup nuggets, more, Huntley hurt as Ravens again lose a starting QB, Steelers' Pickett put in concussion protocol in loss, Jets star DT Williams exits loss with calf injury, Bengals win despite missing Boyd (finger), Higgins, Sources: Saints, coaches, Jordan fined $500K+, Tucker becomes Ravens' career scoring leader, Source: James out for banged-up Bolts vs. Fins, Patrick Mahomes' unreal no-look toss leads to 56-yard touchdown by Jerick McKinnon, NFL Week 14 takeaways: Lions roll, Eagles overpower Giants, Dallas avoids mega upset, Lions first-rounder Jameson Williams scores 41-yard TD on first NFL catch, Tom Brady and Patrick Mahomes show out; more notable NFL Week 14 arrivals. What to know for fantasy: The Cowboys are a three-point underdog, so Prescott managers have their opponent right where they want them. ET | CBS Philadelphia's defense did not allow a single pass play of 20 or more yards in Week 1 against the Falcons, while the Niners' offense was third in explosive pass plays against the Lions with five. See Week 2 rankings. -- Tim McManus, Bold prediction: Donald will have a monster multisack game to that end. Wilson followed up the 2020 opener with five passing touchdowns in consecutive games. Read more. Ratings and projections update daily. Jacksonville added middle linebacker Joe Schobert in the offseason, allowing Myles Jack to move to his more natural weakside linebacker spot. Let's get into the full Week 2 slate, including a meeting between Patrick Mahomes and Lamar Jackson on Sunday night, a battle between two AFC East rookie QBs and Patrick Peterson's return to Arizona. The Colts' secondary proved suspect in Week 1, allowing the Seahawks to pass for four touchdowns. Godwin not worried: Bucs learning life with Brady, 1 p.m. Maybe he throws for just 399 yards instead. Matchup quality: 79 out of 100 FPI win projection: Falcons, 58 percent This rematch of last year's NFC Championship Game . The Saints blitzed him just twice and focused their efforts on taking away Davante Adams & Co. Will that serve as a blueprint for future opponents? Matchup rating: 43.2 | Spread: BUF -5.5 (41), What to watch for: In two games against the Dolphins in 2019, Bills quarterback Josh Allen completed 62.7% of his passes for 458 yards, five touchdowns and zero interceptions, along with 11 rushes for 88 yards and a touchdown. The Saints' defense has taken the next-man-up mentality to the next level early this season, dominating despite several key players missing from last season. Betting nugget: Mahomes is 8-3 ATS for his career in September. MIN-ARI | ATL-TB | DAL-LAC Read more. Read more. Darnold himself said Saints DE Cameron Jordan can "wreck a game.'' Hensley's pick: Chiefs 27, Ravens 24 -- Mike DiRocco, Game picks from our NFL experts Interestingly, the model slightly downgraded the Packers even after they beat a tough opponent in the Seahawks. At 5-foot-8 and 185 pounds, he can play "hide and seek," according to running backs coach Ivan Fears, who has compared Taylor to Dion Lewis and Darren Sproles in terms of his physical stature. Trotter's pick: Browns 34, Texans 17 While this matchup won't determine the game, it'll definitely have an impact and will be fun to watch. He let managers down with just 8.4 points in Week 1, and he faces a Broncos team this week that held Saquon Barkley to 26 yards on 10 carries last weekend. Triplett's pick: Saints 23, Panthers 19 Look for the Steelers' defense to dominate yet another ground game. What to know for fantasy: No player in the NFL accounted for a greater percentage of his team's Week 1 scrimmage yards than Jamison Crowder (45.3%). Betting nugget: Baker Mayfield is just 4-8 ATS over his past 12 starts. Read more. They ran a four-receiver set on a league-high 25% of their snaps last week, and despite the Dolphins' struggles against the run in Week 1, the Bills will commit once again to their passing game. It should be a good defensive battle, and bettors will want to take advantage of the favorable +120 odds on . In a season-opening win over Dallas, Donald knocked down Cowboys linemen as if they were bowling pins and recorded his first sack of the season. ET | Fox -- Marcel Louis-Jacques, Bold prediction: Allen will throw at least three touchdown passes, and the Bills' offense will get back on track. San Francisco should bounce back in Week 2 against the Seahawks. FPI win projection: Chiefs, 75 percent. Lessons from ugly losses by the Packers, Bills and Titans: How their offenses failed in Week 1, what's next. Last season, Jackson ran for 79 yards against Houston, including a 39-yard run (which was his second longest of the season). Brady trolling Falcons ahead of Week 2 matchup? ET | CBS Zach Wilson and Mac Jones, coming off encouraging openers, meet for the first time in what should be a long personal rivalry. ), Jump to a matchup: See Week 2 rankings. Vikings run out of time to see new reality Colts lose Mack for season with torn Achilles Colts sad for Mack, excited about Taylor Rivers brings turnover problems to Colts in Week 1, 1 p.m. What to know for fantasy: Think the Bears, a three-point favorite, will win this game? See Week 2 rankings. Miami's defense, especially the secondary, could cause issues for the Bills, but the Dolphins won't be able to replicate the Steelers' pass rush. -- Tim McManus, Bold prediction: 49ers running back Elijah Mitchell will go over 100 rushing yards for the second straight week to begin his rookie season. The Giants apparently haven't fixed that problem. NFL Draft; NFL FPI; Total QBR; Injuries; More NFL Expert Picks - Week 14 . Those plays are always there for him against a Ravens team that blitzes a lot but leaves itself vulnerable to big throws. He'll also be used on some stunts inside, and that's where he'll get Murray. Already 'cooking': Seahawks' Wilson-Waldron partnership gets off to fast start, 8:20 p.m. Matchup rating: 67.5 | Spread: NO -5.5 (49), What to watch for: Las Vegas is breaking in a new stadium in the most bittersweet of circumstances. Demovsky's pick: Packers 23, Lions 17 Betting nugget: Atlanta is 4-0 ATS in its past four road games. Baltimore's defense looked vulnerable Monday night, when it allowed 33 points in Las Vegas. Game times and networks . ET | CBS See Week 2 rankings. -- Sarah Barshop. The Jags have allowed at least 20 points in each game of the skid. Betting nugget: The Saints covered every game last season that went under the total (six), making them the only team in the league to do so. FPI prediction: KC, 55.7% (by an average of 2.1 points), Matchup must-reads: A promise to his father: Why Orlando Brown left the Ravens for the Chiefs Ravens promote veteran RB Freeman to active roster Chiefs, Mahomes know it can't be just Hill and Kelce Jackson says he's not dwelling on past losses as Ravens prepare to face Mahomes, Chiefs, Monday, 8:15 p.m. Woodyard's pick: Lions 21, Packers 17 Stat to know: The Bengals have the NFL's worst road record of 3-20-1 (.146) since 2018. How will Patriots' Mac Jones handle Cardinals' blitz on MNF? The Colts' secondary proved suspect in Week 1, allowing the Seahawks to pass for four touchdowns. What to know for fantasy: Chargers running back Austin Ekeler has converted just 15.4% of his career red zone carries (the RB average is 18%), so it's worth noting that rookie Joshua Kelley had more touches in the red zone in Week 1. Betting nugget: Teddy Bridgewater is 22-3 ATS on the road as a starter, but one of his rare losses against the spread came in Week 2 of last season at Tampa Bay, when he played for the Panthers. Philadelphia's defense did not allow a single pass play of 20 or more yards in Week 1 against the Falcons, while the Niners' offense was third in explosive pass plays against the Lions with five. FPI prediction: PIT, 66.8% (by an average of 6.2 points), Matchup must-reads: QB Lock shows his leadership in season-opening loss Steelers' Roethlisberger is sore, but elbow is good after first game After drops, Broncos' Jeudy determined to prove 'failure is growth', 1 p.m. Stat to know: Murray threw for a career-high four touchdown passes in Week 1 versus the Titans, with three of those coming on third down. The reason is that as much as Green Bay's defense performed above expectation, its offense fell far short of what the model anticipated. Matchup must-reads: Ryan: Super Bowl loss has 'no bearing' on game vs. Brady, Buccaneers Bucs RB Jones to start despite Week 1 benching Patterson -- now clearly a running back -- finds a role in Atlanta's offense Brady trolling Falcons ahead of Week 2 matchup? Clutch keep-away drive allows Chargers rare drama-free victory Cowboys' McCarthy: 'A challenge' when O-line is in flux again, 4:25 p.m. KC-LAC | NE-SEA | NO-LV, 1 p.m. Read more. See Week 2 rankings. It's a showdown between two of the best young players in the NFL, last year's No. Davenport's pick: Seahawks 28, Titans 24 What to know for fantasy: Including the playoffs, Kareem Hunt has scored five times in his past five games. Cronin's pick: Colts 28, Vikings 24 Betting nugget: Chicago quarterback Andy Dalton is 10-19 ATS in his past 29 starts. See Week 2 rankings. Matchup quality: 48 out of 100 1 receiver? Buffalo Bills. FPI prediction: CLE, 79.3% (by an average of 11.8 points), Matchup must-reads: Texans show blueprint for 2021 success, but not everything is perfect What did QBs Taylor, Mayfield get out of their year together in Cleveland? ET | FOX DiRocco's pick: Titans 17, Jaguars 16 31 out of 32 qualified quarterbacks. The entire city of Chicago is on edge over the Bears. Betting nugget: Baker Mayfield is just 4-8 ATS over his past 12 starts. Read more. He showed in Week 1 that he has made great strides as a passer, but let's not forget he's among the league's most dangerous playmakers when scrambling. Even that might not be enough to fend off Fields. What will Fields do for an encore? TEN-SEA | KC-BAL | DET-GB, 1 p.m. "Every team schemes for a player like Aaron Donald," Colts coach Frank Reich said. Baby's pick: Bengals 28, Bears 24 ET | ESPN -- Todd Archer. Scroll down to take a look at the FPI projections for every matchup on the Week 12 college football slate, with games listed in chronological order. Jump into a draft >>, Bold prediction: Cornerback Bradley Roby will have an interception in his Saints debut after arriving in a trade from Houston last week. Rothstein's pick: Packers 35, Lions 23 Young can be moved around but had his best success as a right end against Jason Peters last week. The Patriots, however, were 9-0 in nine previous such games. If the Cards' defense plays like it did in Tennessee, and Chandler Jones goes for another few sacks, then Minnesota's offense will be stuck in the mud, much like the Titans' was. Especially since the Cowboys didn't need it last week after getting chunk plays through the air against a Tampa Bay secondary that had issues tackling. FPI prediction: PIT, 64.5% (by an average of 5.4 points), Matchup must-reads: Raiders' Crosby not resting on Monday night laurels heading to Pittsburgh Steelers' Watt caps 'heck of a week' by helping lead upset win over Bills Second-half utilization of wide receivers allows Carr, Raiders to find rhythm Carr rallies Raiders past Ravens in wild OT win: 'Hope this is a sign of things to come', 1 p.m. Also, keep an eye on Pittsburgh's Ben Roethlisberger; he needs three passing touchdowns to become the eighth NFL player with 400 passing touchdowns. Can Giants' Slayton continue to produce like a No. Read more. 2d ESPN . But it's hard to see the game playing out the same way, and if the Texans are playing from behind for most of the tilt, it's easy to see how Cleveland's front seven dominates Houston's backs. Betting nugget: The over hit in all three divisional games at Lambeau last season (1-4 in the other five regular-season games Green Bay hosted). 4d Jeff Legwold. In the past four games that he has started and finished, he has thrown for at least 403 yards. -- Rich Cimini, Bold prediction: The Patriots will make running back J.J. Taylor active as a result of rookie Rhamondre Stevenson's struggles in the opener, and Taylor's presence as a complement to Damien Harris and James White will be key against a Jets defense that blitzed 41.7% of the time in the opening week -- the fifth-highest total in the NFL. Pryor's pick: Steelers 31, Broncos 16 Rhodes' debut with the Colts didn't go too well in Week 1 against Jacksonville. Full schedule | Standings Prime-time Parlay is your FPI-based guide predicting the results of all the biggest games of Week 2. . Betting nugget: Unders are 10-2-1 in Arizona games played in the first month of the season since 2018. -- Courtney Cronin, With our live draft lobby, you can be drafting a team in minutes. (He scored 13 times in his first 24 games with the Browns.) Stat to know: Las Vegas quarterback Derek Carr is completing 71% of his passes since the start of last season, second-best in the NFL to Saints QB Drew Brees (73%). . FPI projection: Bears win by 2.9 points, No team blitzed less than the Bears (7 percent of dropbacks) in Week 1. The Seahawks are playing in their 2021 home opener at Lumen Field, where they allowed opposing offenses to score a touchdown on the opening drive only twice last season. The Raiders' and Steelers' offensive lines are works in progress, but Crosby is coming off AFC Defensive Player of the Week honors, while the ink on Watt's four-year, $112 million extension is still wet. Win and it becomes 82%. Betting nugget: This ends the Patriots' streak of being favored in 64 consecutive games. 3 receiver? Read more. Wolfe's pick: Bills 27, Dolphins 16 Los Angeles coach Brandon Staley has said the team needs to work Ekeler into the passing game. Kiper's draft grades for every team The Week 2 NFL schedule for the 2021 season is stacked with great matchups, and we've got you covered with what you need to know heading into the weekend. Keim's pick: Cardinals 21, Washington 17 Weinfuss' pick: Cardinals 31, Washington 24 FPI prediction: ARI, 68.2% (by an average of 6.8 points) Matchup must-reads: Young, Washington's pass rush 'as advertised' in promising start. We'll learn a lot more about that defense when it takes on Drew Brees and the seventh-best offense in New Orleans. Tampa has won five of those games, and AB has found the end zone in all five. -- Jamison Hensley. ET | FOX -- Brooke Pryor, Everything you need this week: Quarterback Joe Burrow is looking for the first road win of his career; he is 0-5-1 with a Total QBR of 45 in six career road starts. ESPN + Continue reading this article and more from top writers, for only $9.99/mo. What are the five must-watch NFL games this week? LV at LAR Fri 1:15AM. For whatever reason, Allen has had the most career success against the Dolphins. See Week 2 rankings. In losing five of six games to the Chiefs since Anthony Lynn took over as head coach, the Chargers' offense has committed 17 turnovers, and their defense has generated only two of them. Coach Kyle Shanahan manages a running back fantasy factory and will have to work more magic with Raheem Mostert out for the foreseeable future. -- Todd Archer. Betting nugget: The over cashed in both Patriots-Jets games last season after being a winning ticket just once in the four seasons prior. Stat to know: Stafford hasn't started a season 2-0 since 2017. 'Don't panic' Tagovailoa already clicking with receiver Waddle, 1 p.m. Matchup rating: 73.5 | Spread: KC -8 (47.5), What to watch for: Keep an eye on the turnover margin. FPI prediction: ARI, 68.2% (by an average of 6.8 points), Matchup must-reads: Young, Washington's pass rush 'as advertised' in promising start Hopkins has championship aspirations with Murray as his QB, 4:25 p.m. But the Ravens have never given up more than 30 points in each of their first two games of a season. As a reminder, Prime-time Parlay is all about the best games -- Thursday, Sunday and Monday's prime-time games, and the top 1 p.m. and 4 p.m. Sunday matchups. Yes, the odds of this happening are slim, but I'll pick Detroit to win at Lambeau Field against a vulnerable Green Bay team. Sam Bradford's magnificent game against the Saints on Monday Night Football prompted more than a two-point bump in the Vikings' offensive FPI. In 10 career starts vs Panthers, he has a Total QBR of 40. The second was the 2019 Packers, who won both of their games against Detroit last season on game-ending field goals despite not holding a lead at any point in either game. NFL FPI NFL FPI; . Jets get help with WRs Crowder, Cole returning, Jets LT Becton to miss at least 4-6 weeks after dislocating knee cap, Jets' protection issues could be pain in neck for QB Wilson, Shirt on or shirt off, elite-version Miller has returned, Opening loss to Texans shows pass rush still a problem for Jaguars, Bridgewater makes the first impression Broncos hoped to see, How Burrow's expectations for himself, Bengals are creating success, Bears offer small glimpse of Fields' potential, Higgins to swap number: 'I'm not Ochocinco 2.0'. Even that might not be enough to fend off Fields. Betting nugget: Mahomes is 8-3 ATS for his career in September. The Jets have cycled through a handful of rookies over the years, but Jones is the Patriots' first rookie starter since Drew Bledsoe in 1993. Matchup quality: 70 out of 100 Stat to know: Since last season's Week 2 game at Miami, Allen's QBR is 78, which ranks third behind Aaron Rodgers and Patrick Mahomes.Allen also has thrown more touchdown passes in 16 starts (36) than he did in 28 starts (32) before that game. But the Cowboys are just 1-3 in those four games and know that is not a long-term formula for success. NFL Expert Picks - Week 14. That's 4.9 points better than FPI's rating of the Broncos, whom the metric has been skeptical of since the preseason. (He has nine touchdowns over that run.) Trubisky leads Bears to comeback, 4:05 p.m. What to know for fantasy: Colts running back Jonathan Taylor has a touchdown -- or the fantasy equivalent of a touchdown (six points) -- as a pass-catcher in each of his past seven games. -- Mike DiRocco, Game picks from our NFL experts Nelson, an All-Pro in each of his first three seasons in the league, will have his hands full -- and might need help, at times -- against Donald, a three-time Defensive Player of the Year. NYJ at BUF Sun 6:00PM. But Murray will still throw for 225 yards in a win. MIN at DET Sun . It's the first time in the 62-year history of the rivalry that rookie QBs are starting against each other. Betting nugget: The Vikings have covered their past five games after a loss. -- Turron Davenport. FPI prediction: NE, 64.8% (by an average of 5.5 points), Matchup must-reads: Will Belichick reduce Harris' workload after fumble? Will Belichick reduce Harris' workload after fumble? Teicher's pick: Chiefs 27, Chargers 20 According to Elias Sports Bureau, Brady looks to become the sixth QB to go 9-0 or better against a single team since starts were first tracked in 1950. Robinson's best game last year came against the Giants, when he had 131 yards receiving and a touchdown. Los Angeles, on the other hand, enters with a 56% chance to make the playoffs. That's how these two quarterbacks are usually described, right? -- Paul Gutierrez. Texas wide receiver DeAndre Hopkins had 287.8 points in 16 games last season. In Week 1, they covered easily, and the under once again cashed. and dropped back to pass on 11 of their 14 first-quarter offensive plays against Atlanta. The Raiders' and Steelers' offensive lines are works in progress, but Crosby is coming off AFC Defensive Player of the Week honors, while the ink on Watt's four-year, $112 million extension is still wet. Goff threw zero touchdowns for the fourth time in his past nine games, while Wentz took those eight sacks. More NFL coverage , Bold prediction: The Broncos' defense will have six combined sacks and turnovers. MIN-ARI | ATL-TB | DAL-LAC Do Giants trust Jones? But the Cowboys are just 1-3 in those four games and know that is not a long-term formula for success. What to know for fantasy: Playoffs included, wideout Antonio Brown has run more than 25 routes eight times in his Buccaneers career, including last week with 36 routes. Matchup rating: 54.6 | Spread: SF -3.0 (49.5), What to watch for: This matchup is all about the explosive plays. Now watch for the two-time NFL Defensive Player of the Year to take advantage of an inexperienced Eagles guard and make it another long day for Wentz. Clutch keep-away drive allows Chargers rare drama-free victory Cowboys' McCarthy: 'A challenge' when O-line is in flux again, 4:25 p.m. NFL Expert Picks - Week 14 . Note: All times eastern. Matchup rating: 35.6 | Spread: TEN -7.5 (44), What to watch for: Titans running back Derrick Henry has tormented the Jaguars to the tune of 498 rushing yards in his past four games against them. What to know for fantasy: Adams was the top scoring player in Week 1 (41.6 points) and has caught six touchdown passes over his past six matchups with the Lions. Irrelevant' to rookie starting QB: The twists and turns of Brock Purdy's journey to the 49ers. PickCenter | ESPN Chalk Keim's pick: Cardinals 21, Washington 17 Weinfuss' pick: Cardinals 31, Washington 24 FPI prediction: ARI, 68.2% (by an average of 6.8 points) Matchup must-reads: Young, Washington's pass rush 'as advertised' in promising start. See Week 2 rankings. Stat to know: This marks the second career meeting between the top two picks of the 2016 NFL draft, Wentz and Jared Goff.Wentz won the first in 2017 with four passing touchdowns. BUF-MIA | LAR-IND | NO-CAR FREE to play! Baker Mayfield, who took over for Taylor as a rookie during the 2018 season, praised Taylor for his leadership and mentorship this week. -- Michael Rothstein. What the Lions do -- and how well they do it -- might help determine what kind of coverages Rodgers sees throughout the season. * next to the pick means the team will win, but not cover. If he reaches 100 yards against the Eagles, he would have the most receiving yards in the first two games of the season by a 49ers player in team history. ET | CBS Rothstein's pick: Buccaneers 35, Falcons 24 Jump into a draft >>, Bold prediction: Cornerback Bradley Roby will have an interception in his Saints debut after arriving in a trade from Houston last week. People are talking about the NFL's offensive explosion and Bills fans are probably thinking, "huh?" Buffalo's offense -- under Josh Allen, Nathan Peterman or Derek Anderson, it doesn't matter -- is hard to . Matchup rating: 45.8 | Spread: CLE -12.5 (48), What to watch for: How will Houston quarterback Tyrod Taylor perform in his return to Cleveland? -- Mike Triplett. Yes, Von Miller is out for the year, Bradley Chubb is still working his way back from last season's ACL surgery and the Broncos were tepid in the pass rush in much of their Week 1 loss to the Titans. Los Angeles coach Brandon Staley has said the team needs to work Ekeler into the passing game. -- Jenna Laine, Bold prediction: Matt Ryan will have a 300-yard, three-touchdown day against Tampa Bay -- but it still results in a loss. Matchup rating: 58.4 | Spread: ARI -3.5 (50.5), What to watch for: Sure, all eyes will be on Kyler Murray just because of his unpredictability and excitement levels. What to know for fantasy: Alvin Kamara has scored north of 19 fantasy points in five straight games against the Panthers, getting at least 20 touches of multiple touchdowns in each of those contests. AMAZON. Especially since the Cowboys didn't need it last week after getting chunk plays through the air against a Tampa Bay secondary that had issues tackling. FPI prediction: BUF, 50.2% (by an average of 0.2 points), Matchup must-reads: After Bills' sloppy mistakes led to season-opening loss, what's the message? The Texans have allowed quarterbacks to average 5.6 yards per rush since the start of 2019, which is the second-worst average over that span. Watt done 'tiptoeing' around his training, Jones: Contract will come as sacks pile up, A healthy Murray makes Cardinals a contender, Ryan: Super Bowl loss has 'no bearing' on game vs. Brady, Buccaneers, Bucs RB Jones to start despite Week 1 benching, Patterson -- now clearly a running back -- finds a role in Atlanta's offense. Stafford is coming off a huge Week 1 performance that saw him pass for 321 yards and three touchdowns, with no interceptions, in a 20-point win over the Bears. Betting nugget: The total has gone under in nine of Arizona's past 11 September games. NFL FPI NFL FPI; Total QBR Total QBR; . And they might need to do it again, with top CB Marshon Lattimore now dealing with a thumb injury. ET | CBS What to know for fantasy: Eagles tight end Dallas Goedert has 6.1 more fantasy points over his past five games than Zach Ertz does. In April, they finally became teammates when the Eagles acquired Brown from the Tennessee Titans for the 18th and 101st overall picks -- a move Hurts championed and helped get to the finish line. Stat to know: The Titans have allowed more than 35 points in their past three regular-season games. The duo got off to a solid start against Houston, but this week will be significantly harder. Projected winner: According to ESPN's Football Power Index, UTSA is projected to notch its second straight win on Saturday when it travels to face Southern Miss. Do Not Sell or Share My Personal Information. The Saints' defense has taken the next-man-up mentality to the next level early this season, dominating despite several key players missing from last season. -- David Newton, Any Day Can Be Draft DayWith our live draft lobby, you can be drafting a team in minutes. FPI prediction: CHI, 54.2% (by an average of 1.6 points), Matchup must-reads: How Burrow's expectations for himself, Bengals are creating success Bears offer small glimpse of Fields' potential Higgins to swap number: 'I'm not Ochocinco 2.0', 4:05 p.m. Prediction: 49ers 24 . -- Jenna Laine, Bold prediction: Matt Ryan will have a 300-yard, three-touchdown day against Tampa Bay -- but it still results in a loss. Next week, the Cleveland Browns, whom Burrow has yet to . Also, keep an eye on Pittsburgh's Ben Roethlisberger; he needs three passing touchdowns to become the eighth NFL player with 400 passing touchdowns. Davenport's pick: Titans 20, Jaguars 14 PickCenter | ESPN Chalk Since then, he has joined Emmitt Smith (23), Marcus Allen (17) and Todd Gurley (15) as the only running backs to score at least 15 fantasy points in 15 straight games. See Week 2 rankings. The Eagles should be a bit better slowing the run than Detroit was, but this is a defense that looks vulnerable at the second level, which could make them susceptible to Mitchell's one-cut-and-go ability. Stat to know: Since last season's Week 2 game at Miami, Allen's QBR is 78, which ranks third behind Aaron Rodgers and Patrick Mahomes. Stat to know: Mahomes and Lamar Jackson have the two highest Total QBRs among quarterbacks to appear in 10-plus prime-time games since the metric began in 2006. Jackson is 0-3 in his career versus the Chiefs, largely due to accuracy issues, failing to complete 55% of his passes in any of those three matchups. Betting nugget: The over cashed in both Patriots-Jets games last season after being a winning ticket just once in the four seasons prior. -- Mike Triplett. FPI prediction: PIT, 64.5% (by an average of 5.4 points), Matchup must-reads: Raiders' Crosby not resting on Monday night laurels heading to Pittsburgh Steelers' Watt caps 'heck of a week' by helping lead upset win over Bills Second-half utilization of wide receivers allows Carr, Raiders to find rhythm Carr rallies Raiders past Ravens in wild OT win: 'Hope this is a sign of things to come', 1 p.m. -- Mike Reiss. FPI win projection: Jaguars, 57 percent -- Marcel Louis-Jacques, Bold prediction: Allen will throw at least three touchdown passes, and the Bills' offense will get back on track. Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score picks. -- Jamison Hensley, Bold prediction: Mahomes will complete six throws of at least 20 yards. -- Adam Teicher. What to know for fantasy: Think the Bears, a three-point favorite, will win this game? -- Josh Weinfuss, Herbert makes case to get paid Unlike the Titans, Minnesota will attempt to help its tackles against Jones, but it won't be enough. That's the most double-digit favorites in a week this early in the season since Week 1 of 2009. Laine's pick: Buccaneers 34, Falcons 21 And with Russell Wilson putting on a four-touchdown performance in Week 1, it is entirely possible that Titans streak continues. That's saying a lot considering how Tennessee gained a total of only four yards on their first four drives last week. Matchup quality: 65 out of 100 3 receiver? A sack in this one would put them in a tie for the fifth-longest streak. Wells' pick: Colts 27, Vikings 23 What to know for fantasy: Rodgers had no touchdown passes and two interceptions Week 1 at the Saints. ET. Stat to know: Jameis Winston looks to lead the Saints to their first 2-0 start since 2013. Now it believes Dallas is the third-best team in the NFL, behind the Chiefs and Patriots, with an overall FPI of +5.0. We have to be able to make some in-game adjustments." Not bold enough? The Chargers (6-5) entered the week with a 64% chance of making their first postseason appearance since 2018. -- Paul Gutierrez, Relive the NFL's greatest games, original series and more. Stat to know: Since last season's Week 2 game at Miami, Allen's QBR is 78, which ranks third behind Aaron Rodgers and Patrick Mahomes.Allen also has thrown more touchdown passes in 16 starts (36 . Fantasy Football Cheat Sheet: All you need to know to win in Week 14, From 'Mr. ET | CBS ESPN's FPI predicts every Week 4 game. Read more. What to know for fantasy: Chiefs wideout Tyreek Hill has 310.6 fantasy points over his past 12 games (playoffs included). Henderson's pick: Seahawks 30, Titans 24. It'll be his second straight week crossing the century mark, putting him on his way to matching the historic streak he set in 2018 when he started the season with eight straight 100-yard receiving performances. "That's ridiculous," Lynn said. ET | ESPN A loss would drop that to a 38 percent chance at the division, and 49 percent at making the playoffs. McShay's favorite pick for all 32 teams Not so fast Adams fires back at Jets' Gregg Williams; not 'bored' in Seahawks debut, Monday, 8:15 p.m. -- Brooke Pryor, Bold prediction: Maxx Crosby and Watt will repeat their respective opening-week performances and both get two more sacks apiece. Read more. On the other side, the Cowboys need a big day from their offense to avoid an 0-2 start. Mahomes has an eight-game winning streak in prime-time contests, the longest active streak of any quarterback. Matchup rating: 38.7 | Spread: NE -6.0 (43), What to watch for: Here come the rookie quarterbacks. Penalties won't hurt Minnesota's offense like they did in Week 1; that responsibility belongs to the Cardinals' defensive front, which will wreak havoc against the Vikings' struggling O-line. 1 pick and this year's No. Cutting down on those mistakes against Atlanta will be key. The Falcons will find a way to get on track offensively; Ryan had 621 yards and five touchdowns in two games against the Buccaneers last season. The Giants have said all week it's imperative to get the run game back on track against the Commanders, who come into the contest with the NFL's eighth-best run defense (averaging 108.4 yards per . The Lions played man coverage on 82% of their defense snaps in Week 1, the highest rate of any team on opening weekend. Thiry's pick: Rams 32, Colts 17 Week 14 inactives: Who's in and who's out? How will Patriots' Mac Jones handle Cardinals' blitz on MNF. Week 14's Sunday slate brings us an abundance of intriguing NFL matchups, including the Cincinnati Bengals (-6, 46.5) hosting the division-rival Cleveland Browns, the New York Jets going for a season sweep of the Buffalo Bills (-9.5, 43), the Philadelphia Eagles (-7, 45) visiting the New York Giants, and the San Francisco 49ers (-3.5, 37.5 . Falcons' Jones 2nd-fastest WR to record 800 catches Cowboys' Elliott shows off 'Feed Me' tattoo on stomach Sources: Cowboys' Lee had surgery, out until mid-October, 1 p.m. Cronin's pick: Cardinals 30, Vikings 17 Last week, a tough win in Tennessee. Read more. See Week 2 rankings. Rothstein's pick: Buccaneers 35, Falcons 24 Jackson is 0-3 in his career versus the Chiefs, largely due to accuracy issues, failing to complete 55% of his passes in any of those three matchups. We ought to keep the same thing in mind about Ryan Fitzpatrick despite his Week 1 dominance. The Giants might present Trubisky with an opportunity to have a more balanced performance on Sunday. See Week 2 rankings. New Orleans Saints at Las Vegas Raiders. FREE to play! This is a new feel for the Patriots-Jets series, which was dominated by a veteran quarterback (Tom Brady) for two decades. The Cowboys received a decent-sized FPI upgrade after handily beating the Giants, whom the model previously had pegged as having the best defense in the NFL. Stat to know: Mahomes and Lamar Jackson have the two highest Total QBRs among quarterbacks to appear in 10-plus prime-time games since the metric began in 2006. 3. See Week 2 rankings. We have to be able to make some in-game adjustments." Vegas isn't far behind, since it made Baltimore road favorites. Sunday, another tough win over Kansas City. Keim's pick: Cardinals 21, Washington 17 See Week 2 rankings. Baby's pick: Bengals 28, Bears 24 Dickerson's pick: Bears 21, Bengals 20 FPI prediction: CHI, 54.2% (by an average of 1.6 points) Matchup must-reads: How Burrow's expectations for himself, Bengals are creating success. ET | Fox Betting nugget: The Chargers covered their final two home games of 2020 after failing to cover seven of their previous nine games at their place. -- Cameron Wolfe, Bold prediction: The Bills will have two 100-yard receivers on Sunday. More NFL coverage , Bold prediction: The Broncos' defense will have six combined sacks and turnovers. Whether he suits up will be something to keep an eye on. But the most important aspect to watch on Sunday is how the Cardinals' front seven pressures the Vikings' offensive line and whether it can get to Kirk Cousins, who threw for 351 yards and two touchdowns last week. Pick NFL winners straight up or against the spread and compete to win more than $14,400 in prizes! Betting nugget: The Steelers have had just one losing ATS season at home since 2010 (3-5 ATS at home in 2017). Transactions | Injuries Both rushed for seven touchdowns in 2019, but they also each scored eight touchdowns (with no interceptions) when passing on the run, according to ESPN Stats & Information research. ET | CBS Pryor's pick: Steelers 24, Raiders 17 And they haven't started 0-2 in a season since 2017. Even still, it's no surprise that this showdown pits what FPI considers to be the second-best offense (Atlanta) against the sixth-best offense (Green Bay). ET | FOX Godwin not worried: Bucs learning life with Brady, Early returns exciting for Allen in Bills' revamped passing game, Dolphins' defense faces Week 2 test: Stop another QB from running, Jaguars' Henderson thinks great debut could have been even better, Titans' Byard can share home-birth story with his son 'for the rest of our days', Fourth-quarter comebacks becoming routine for Tannehill, Titans. Betting nugget: Teddy Bridgewater is 22-3 ATS on the road as a starter, but one of his rare losses against the spread came in Week 2 of last season at Tampa Bay, when he played for the Panthers. Injuries: Bills | Dolphins What to know for fantasy: Wideout Stefon Diggs had 15.9 fantasy points -- nine catches for 69 yards -- in the Bills' Week 1 . It all culminates with a Monday Night Football matchup between the Lions and the Packers on ESPN. Matchup rating: 37.6 | Spread: GB -11.0 (48), What to watch for: How will the Lions try to defend Aaron Rodgers and the Packers' offense? 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